DENSITY & POWER+ Stack!
- 1 Breakthrough DENSITY
- 1 Breakthrough POWER+
A PUMP PRODUCT THAT ACCELERATES BLOOD FLOW, INCREASES ENDURANCE, AND ENHANCES FOCUS!
Breakthrough DENSITY is designed to:
- Skyrocket blood flow & pumps
- Increase energy & strength
- Enhance mood & mental focus
How can this be? It contains the best N.O. ingredients at appropriate dosages:
What Does Arginine Alpha Ketoglutarate (AAKG) Do?
AAKG, also commonly known as Arginine AKG or arginine alpha ketoglutarate, contains the essential amino acid, L-arginine. Human biochemistry depends on arginine to perform various important functions.
It assists with the elimination of ammonia by regulating the urea cycle. Arginine also serves to promote healthy functioning of the immune system. Further, it is known to be a key player in protein synthesis.
Alpha ketoglutarate is vitally important for the efficient metabolism of certain amino acids, as well as for accommodating the production of energy. AAKG is also used during heart surgeries for its vasodilator properties, helping to ensure that there are no blood delivery issues during the procedures.
It is also administered to many post-surgery patients to prevent muscular breakdown. Finally, it is effective at treating certain bacterial infections, and recurring yeast infections.
Therapeutic Benefits of AAKG
Arginine AKG is therapeutically used to treat liver issues, kidney disease, cataracts and various stomach and intestinal disorders.
Further, it is effective at relieving symptoms of erectile dysfunction and sterility in men. AAKG is also used to increase sexual desire and performance.
However, the most common usage of AAKG supplements is for bodybuilding and athletic performance purposes. Because it assists the liver in breaking down harmful substances, like ammonia, it allows for longer, less painful workouts.
L-arginine, being an amino acid, is also beneficial for the development of lean muscle mass. AAKG is favored by weightlifters, bodybuilders and various other performance athletes because it increases nitric oxide production, which in turn increased generalized vasodilation.
Clinical Support for AAKG Benefits
L-arginine alpha ketoglutarate supplementation has been researched extensively in various laboratory settings. It is known that when arginine is released into the bloodstream, there is a significant increase in nitric oxide production.
With more nitric oxide present, extended muscle pumps, enhanced work capacity, elevated libido and improved recovery times are likely.
L-Arginine Hydrochloride (HCL) Supplement Benefits & Safety
L-arginine hydrochloride (HCL) is a formulation for the amino acid L-arginine that is sometimes used in dietary supplement.
L-arginine HCL is used for exercise performance, erectile dysfunction, immune system performance and cardiovascular conditions, such as hypertension (high blood pressure).
In humans, L-arginine is involved in protein synthesis and is a substrate for the enzyme nitric oxide synthase (NOS).
NOS acts on L-arginine to produce nitric oxide, which is a vasodilator. Vasodilators trigger vasodilation, which is characterized by the expansion of blood vessels and the relaxation of smooth muscle tissue.
The hydrochloride form of L-arginine shows improved bioavailability compared to L-arginine. Oral L-arginine supplements have been observed to temporarily increase nitric oxide levels, which can have benefits for bodybuilders, athletes and men’s health.
L-arginine is a semi-essential amino acid.
This means that the body normally produces sufficient levels of L-arginine, but in rare cases supplementation may be required.
Individuals suffering from protein malnutrition, excessive lysine production, burns, or excessive ammonia production may need to supplement L-arginine.
Deficiency is not a common condition in developed countries.
However, even in non-deficient individuals, supplementing with L-arginine hydrochloride may have benefits for athletic performance, circulation and general health.
Although L-arginine is produced by the human body, it can also be consumed through one’s diet. L-arginine may be obtained by consuming complete proteins, such as those in meat, dairy and beans, as well as select incomplete proteins, such as the ones found in spinach, garlic, grapefruit and strawberries.
L-Arginine and Nitric Oxide
As noted, L-arginine is the substrate for the enzyme that produces nitric oxide. Nitric oxide is an important signaling molecule in the human body.
One of its many physiological effects is that it induces vasodilation, which is characterized by the widening of blood vessels and the relaxation of smooth muscle tissue.
These characteristics of nitric oxide make it an important signaling molecule. In fact, scientists Robert Furchgott, Louis Ignarro and Ferid Murad were awarded the 1998 Nobel Prize in Medicine or Physiology for their work in identifying NO as a signaling molecule in the cardiovascular system.
L-Arginine Hydrochloride is most commonly supplemented as a natural Nitric Oxide booster for bodybuilders. Nitric Oxide supplements can also support sexual function and improve symptoms of Erectile Dysfunction.
Nitric Oxide and the Human Body
When nitric oxide levels are low, blood circulation slows and areas of the body may not receive an appropriate blood supply. Thus, most complications that arise from low nitric oxide levels are connected to the heart and blood vessels.
For instance, men who experience low nitric oxide may experience erectile dysfunction, decreased libido and may become easily fatigued.
Other complications that arise from low nitric oxide levels include restless leg syndrome, clogged arteries, loss of feeling in the limbs, cold hands and feet, high blood pressure, congestive heart failure, chest pain, coronary artery disease and decreased mental capacities.
Nitric oxide opens blood vessels, which may improve circulation and oxygen delivery. Oxygen is transported throughout the body via the blood.
Thus, when blood flow is decreased or restricted, the body does not receive enough oxygen. Lack of oxygen caused by poor circulation may cause many daily activities to become exhausting endeavors.
L-Citrulline Benefits & Uses
L-citrulline is typically used by bodybuilders as a pre-workout supplement and by men who want to improve their sexual performance. It is a safe and natural Nitric Oxide booster, promoting increased circulation.
L-Citrulline Mechanisms of Action
L-citrulline is used to accommodate certain processes in the urea cycle (ornithine cycle). The urea cycle is a set of biochemical reactions that prevents accumulations of nitrogenous substances like ammonia in the cells.
Substances like ammonia and lactic acid are normal byproducts of cellular metabolism. If they are not kept within proper cellular concentrations, serious side effects may result.
L-citrulline is also converted into arginine in the body and is more effective at increasing serum levels of this amino acid than consuming L-arginine directly. This is due to its improved absorption from the intestinal tract and better bioavailability.
Common L-Citrulline Uses
L-citrulline is used for muscle fatigue, muscle weakness, erectile dysfunction (ED), dementia, Alzheimer’s disease, high blood pressure (hypertension), cardiovascular and vascular disease, diabetes mellitus, heart failure, ischemia-reperfusion injury, poor immunity responses, sickle cell anemia, Reye’s syndrome and more.
In children, L-citrulline is used intravenously for postoperative pulmonary hypertension.
Bodybuilders and some other athletes use L-citrulline to improve athletic performance, increase their energy levels and prolong endurance during both aerobic and anaerobic exercise sessions.
There are no L-citrulline side effects associated with using it against certain urea cycle disorders. These conditions are rare and may cause deficiencies in certain enzymes, especially in children.
These enzymes are responsible for removing nitrogenous compounds from the bloodstream. If these substances are not kept within proper levels, then brain damage, coma and/or death may occur.
Agmatine Sulfate Review + Benefits
Agmatine Sulfate is a biogenic amine that is derived from the amino acid L-Arginine. This occurs due to a process called decarboxylation, which is the removal of a carboxylic acid group from the amino acid.
The resulting compound, Agmatine Sulfate, appears to be stored within the neurons of the brain and is released as these neurons become activated.
Due to this interesting process and storage mechanism, Agmatine Sulfate has actions and activities that are very different from its predecessor. It also appears to be a promising supplement in terms of neuropathic pain, drug addiction, stroke protection, and even general cognitive health. It is also considered to be a novel neurotransmitter, or at the very least a neuromodulator.
HOW IT WORKS:
- Regulates Nitric Oxide synthesis
- May promote muscle growth & stamina
- Improves post-workout recovery
Agmatine Sulfate Effects:
The primary method of action for Agmatine Sulfate is by crossing the blood-brain barrier, entering into the central nervous system, and then binding to NMDA Glutamate receptors.
Since this is the chief neurotransmitter involved in synaptic plasticity and memory function, this may be responsible for a number of the associated cognitive benefits of this supplement.
The supplement also appears to help regulate the levels of Nitric Oxide. This is especially true in cases where this chemical has been improperly elevated. It also inhibits, or blocks, calcium channels.
Agmatine Sulfate also has some analgesic activities, releasing a number of opioid and endorphin chemicals, seeming to have some sort of synergistic effect on many of these chemicals.
It is also capable of enhancing the effects of both morphine and fentanyl to increase pain killing, reduce tolerance, and lower addiction. It even appears to work in synergy with marijuana.
Agmatine Sulfate Benefits:
There are a number of benefits associated with this supplement. In fact, it appears to do much of the same things as Arginine but at a greater rate of potency. It has a decidedly Nootropic effect and can help people achieve a mental edge, whether in or out of the gym or athletic training.
The supplement supports a healthy mood, has anti-anxiety properties, and may also stack very well with other Nootropic supplements like Aniracetam and other Ampakines.
Agmatine Sulfate also acts as an anti-oxidant. Part of this benefit is due to the fact that it helps to limit the activity of Glutamate and thus, over excitation of the brain. Many people will take Agmantine Sulfate to prevent excitotoxicity which can occur when using too much Sunifiram, Unifiram, Modafinil or other similar nootropic supplements. Removal of free radicals, toxins, and other poisons can help to keep not only the brain but the entire body in a better state of health.
There are also a number of athletic effects. This includes enhancing and improving insulin response of the body. This has long been thought to be one of the biggest keys to building a leaner, harder, and more muscular body.
The supplement is additionally thought to stimulate the production and increase of GH and LH hormones which can also have positive effects upon overall body composition. Due to the regulation of Nitric Oxide levels in the body, Agmatine Sulfate may also lead to better muscle “pumps” in weight training athletes.
Another key benefit is that this supplement seems to act as an analgesic. This can be very beneficial for the relief of pain. Agmatine is observed to release several types of endorphins and natural opioid substances in the brain. It has also been used in conjunction with morphine and marijuana, having a synergistic effect. Some researchers feel that there may be therapeutic uses for Agmatine in helping to treat addictions.
Agmatine Sulfate Review:
There are a large number of potential benefits associated with Agmatine Sulfate. Just the range of these potential helps is enough to consider at least trying it and seeing what effects it will have on you personally.
The idea of being able to protect the brain, relieve pain, and help increase insulin production and response from a single supplement does sound extraordinary. Agmantine is also very promising for regular users of Glutamatergic Ampaine nootropics that want to protect the brain against excitatory neurotoxicity.
This supplement is continuing to be researched for its possible anti-aging and life extension or longevity promoting benefits.
Noopept Review for Beginners: How to Use this Nootropic
Noopept is one of the most effective and strongest of all the Nootropic supplements on the market today.
It has been found improve memory, learning capacity, focus, and concentration.
This guide is designed to explain some of the positive benefits of Noopept, how the supplement actually works, proper dosage levels, and even ways to combine it with other Nootropics for improved or additional benefits.
- Supports memory, focus & mood
- Boosts mental alertness & energy
- Increases BDNF & promotes brain health
Review of Noopept Benefits:
Most people turn to Noopept because they are hoping to increase their brainpower and experience cognitive enhancement.
Certainly, a number of users and studies have shown that this can be very effective at increasing memory and learning abilities.
Speed of memory recall may also be improved.
Different people will experience these effects in different ways. Some may find them to be subtle improvements, such as being able to hold conversations longer and with much less effort (and then remember every detail later).
Others may see some significant improvements when taking Noopept powder and are subsequently able to remember almost everything. The same goes for enhanced learning capacity.
Mental energy is also improved. This can be compared to lifting a type of brain fog. Everything will become more clear and require less thought when supplementing with Noopept. Attention span is improved along with greater concentration and focus.
In this regard many users also are able to see significant improvements in their levels of stress and anxiety. You may feel that using Noopept powder can increase your productivity, motivation and drive.
The supplement is also important for supporting overall brain health. Noopept is actually considered a neuroprotectant, meaning that it has the ability to help protect the neurons in the brain from damage.
Much as an anti-oxidant is able to rid the body (or brain) of toxins and poisons, so can Noopept. Stress caused by oxidation is reduced, and many researchers also think that damage from excessive alcohol consumption may also be reduced.
Overall brain communication is also improved. The development of connections and growth of new synapses that connect the left and right hemispheres of the brain are greatly facilitated while taking Noopept. This allows for some interesting and unique integrations between functions and abilities normally associated with particular side of the brain.
It is also this integration process which many researchers have postulated as the main reason for long-term memory improvement as well as the anti-anxiety benefits promoted with this supplement.
How Noopept Works?
Noopept is actually absorbed by the body from within the GI tract where it then circulates to the brain and crosses the blood-brain barrier with ease.
The substance is capable of reaching maximum concentration within about 15 to 20 minutes making it one of the fastest acting nootropic supplements available.
Noopept (which is a peptide chemical compound) then travels to specific Glutamate receptor sites within the brain. It binds with these sites and helps to inhibit the breakdown of Glutamate which is one of the most powerful neurotransmitters relative to cognitive function.
Noopept also stimulates these receptors to be more sensitive to Glutamate so that they are activated more readily. The Glutamatergic system is believed to be vitally important in memory formation, learning, and other cognitive processes that we typically associated with increased intelligence.
Another interesting way in which Noopept works is by helping to increase the amount of oxygen within the brain. This main be one of the reasons why many users report a feeling of clarity, even sometimes from among the first moments of taking this supplement.
Glucose metabolism in the brain is also enhanced. Glucose (sugar) is the main source of energy in the brain and when you improve its metabolism you make it more available for the brain to tap into. This is another possible explanation for the increased brain energy, mental clarity, focus, and concentration that occurs after taking Noopept.
As a dietary supplement, take four (4) capsules about 30-45 minutes prior to exercise. An additional capsule may be taken once the user’s tolerance has been assessed. DO NOT EXCEED 4 capsules in a 24 hour period.
Consult with your physician before using this product. Do not take this supplement if you have any pre-existing medical conditions. This product should not be used by anyone under the age of 18. Athletes, check with your testing organization before using. User assumes all risks and liabilities related to use of this product. Keep out of the reach of children. Keep in a cool, dry place.
SIZE, STRENGTH, & PUMP CATALYST!
Breakthrough POWER has been a staple at AdvancedSupps.com since its launch in July 2017. It's been a complete hit for muscle strength and growth without the bloating or loading of many creatine products. It incorporates Creatine Pyruvate, along with Creatine Hydrochloride, to increase endurance and buffer lactic acid in the muscle.
It was designed to be the unique and ideal Creatine product that it became.
BUT NOW THERE IS POWER+!
POWER+ is the original Breakthrough POWER Creatine Product PLUS Additional Pump + Strength + Mass catalysts! It combines the old Breakthrough POWER formula with Methyl-D-Aspartic Acid, Tribulus, LongJack, and enteric coated capsules to become the brand new Super-Charged Breakthrough POWER+ from Breakthrough Labz!
Inspired by BioRhythm's Methyl CreaTest, one of the most popular products we've ever carried
Methyl CreaTest featured 200mg of Methyl-D-Aspartic Acid, the methylated and much more powerful derivative of D-Aspartic Acid (DAA).
POWER+ contains 2.5 times the amount of Methyl DAA as Methyl CreaTest!
Methyl CreaTest also combined libido-surging LongJack and vascularity-enhancing Vanadyl Sulfate.
LongJack and Tribulus are added to the new POWER+ for that libido-surge and mood enhancement to get you going at the gym.
Vanadyl Sulfate from Methyl CreaTest is replaced with BMOV, an organic form of Vanadium that is essentially the combination of Vanadyl Sulfate with Maltol, giving it more than twice the biological activity of Vanadyl Sulfate. It boosts endurance, supports muscle growth and hardness, reduces cholesterol, increases satiety, mimics insulin, and decreases sugar absorption (detering sugar away from intestinal absorption and instead into the muscles for use as energy).
Let's not forget POWER+ utilizes Enteric Coated Capsule Technology, effectively doubling the strength of the product versus the identical product using regular capsules that are destroyed in the stomach and poorly absorbed.
To recap, what's so great about POWER+?
- Breakthrough POWER was awesome in the begin with, but here's the supercharged version
- Methyl D-Aspartic Acid = 500mg (2.5x that of BioRhythm's popular Methyl Createst)
- Addition of Tribulus and LongJack = mood + test + libido boosting
- Enteric Coated Capsule Technology = Higher Rate of Absorption!
Reasons for using Breakthrough POWER+
- Boosts muscle strength & growth
- No bloating or loading required
- Increases endurance and buffer lactic acid in the muscle
- Enhances mood, test, and libido pre-workout
- Pushes sugar towards the muscles to use as energy
- Gives you that extra push to train longer and harder at the gym
A LOOK AT THE KEY INGREDIENTS
Creatine HCL (Hydrochloride): What is it?
Creatine is a naturally occurring chemical found within the body, normally in the muscles. It is also found in certain foods and may be obtained through supplementation. It is widely used among athletes in a wide range of sports for the primary purpose of supplementing exercise performance and promoting lean muscle. Creatine HCL is one of the newest iterations of creatine to hit the market; however, it is also significantly more potent.
One form of creatine most impressive is creatine hydrochloride, which is creatine attached to hydrochloric acid. One study found that creatine hydrochloride was absorbed by the body more than 60% better than creatine monohydrate. This allows for a lower dose of creatine to be needed, as well as enhanced results. It also prevents stomach discomfort and any water retention under the skin that some report with creatine monohydrate.
This is the primary difference between Creatine HCL and other types of creatine like monohydrate. It does not require a loading phase and calls for a significantly smaller dosage while still delivering the same benefits.
Creatine HCL Benefits
Creatine hydrochloride’s main benefit is helping to supplement healthy muscle. This is thought to be due to an increase in the production and supply of ATP to working muscle cells. This also promotes muscular energy, helping to avoid lactic acid build-up and allowing for longer and more intense workouts.
What Is Creatine Pyruvate?
Creatine pyruvate is a novel form of creatine that is designed to enhance creatine’s absorption over the traditional form of creatine, namely, creatine monohydrate. Creatine pyruvate is 60% creatine and 40% pyruvate by weight.
Benefits of Creatine Pyruvate
Creatine pyruvate has the advantage of being better soluble in water than creatine monohydrate and thus can be sold as a component of sports drinks or in the form of effervescent tablets. After ingestion, the creatine-pyruvate molecule in the acid environment of the stomach rapidly splits to form creatine and pyruvate, and thus from a theoretical point of view might also combine the beneficial effects of creatine supplementation on the one hand, and the presumed ergogenic action of pyruvate on the other hand. Indeed, sponsored advertisements claim that the bioavailability of creatine originating from creatine pyruvate ingestion is better than for creatine monohydrate. Studies comparing the two forms have shown creatine pyruvate has the same beneficial properties of creatine monohydrate with regard to muscle strength, size and power in response to weight training.
In addition, one big advantage to creatine pyruvate is that it has pyruvate, which boosts endurance and buffers lactic acid in the muscle, allowing you to train harder for longer.
What is BMOV (Potent form of Vanadyl Sulfate)?
Vanadyl Sulfate and BMOV are derived from the trace mineral Vanadium. BMOV is simply Vanadyl Sulfate complexes with Maltol, a naturally occurring food additive. Most recent studies suggest that BMOV has about twice the biological activity of Vanadyl Sulfate.
BMOV boosts endurance, supports anabolism, and promotes muscle hardness.
Vanadyl Sulphate mimics insulin action that helps to improve glucose tolerance, inhibits cholesterol synthesis, and improve mineralization of bones and teeth. And soo, BMOV is also a potent insulin mimic. Results have shown that BMOV significantly decreases plasma glucose levels in diabetic rats at all given doses, and restores hyperglycemic values to normal. BMOV inhibits protein tyrosine phosphatases.
Benefits of BMOV:
- Increasing muscle growth. BMOV boosts endurance, supports anabolism, and promotes muscle hardness.
- Helping with blood glucose. Vanadium in small doses may play a role in weight loss by reducing sugar levels in the blood.
- Reducing sugar absorption. The element, V, deters sugar away from intestinal absorption and toward muscles for use as energy.
- Increasing satiety. Consuming vanadium may make you feel more full.
- Mimicking insulin. Improving glucose tolerance.
What is N-Methyl-D-Aspartic-Acid?
(NMDA) is an amino acid antagonist. When consumed it is shown help improve the production of growth hormone, FSH and LH, making it a powerful testosterone production catalyst.
What does N-Methyl-D-Aspartic-Acid do?
N-Methyl-D-Aspartic Acid binds to NMDA receptor sites in the brain, mimicking the effects of glutamate, the primary neurotransmitter in the central nervous system.
When NMDARs become activated, it stimulates the secretion of Pregnenolone (P5); a steroid hormone that is a precursor to mineralocorticoids, estrogens, androgens, glucocorticoids, neuroactive steroids and progesterones.
Increased levels of these hormones can improve mental energy levels, mood and more.
The activation of the NMDA receptor sites also promotes the synthesis and utilization of anabolic hormones via the endocrine system.
This means that increasing NMDA activity may affect levels of testosterone, HGH (human growth hormone), LH (luteinizing hormone), FSH (follicle stimulating hormone), and other androgenic hormones.
We do know that NMDA receptors in the brain are involved in regulating testosterone secretions and supplements that stimulate these receptors have been shown to increase testosterone levels in men with low levels.
Benefits of N-Methyl-D-Aspartic-Acid?
- Enhances athletic performance
- Increase energy levels and mood
- Boosts Libido
- Increases Testosterone
- Raises LH, FSH, HGH levels
- Boosts cognitive function
MORE ON ENTERIC CAPSULE TECHNOLOGY
This delivery system is known as an enteric coating. This is usually only used with advanced pharmaceutical products.
The enteric coating that we use contains a pH sensitive polymer, which means that it remains intact in the acidic environment of the stomach (pH 1.5 - 3.5), protecting the contents of the tablet.
After passing through the stomach the coating then disintegrates in the small intestine (duodenum) which has an alkaline environment (pH 6.5 - 7.6).
The enteric coating is inert and simply passes through your system without any effect at all. The coating we use is manufactured by Colorcon, a world leader in the development and manufacturing of delayed and immediate release coatings for both pharmaceutical and dietary supplement products. This coating has been thoroughly proven for both safety and efficacy.
Apart from the protection that this system provides for those ingredients in our enteric coated products which could be damaged by stomach acid, it also prevents any irritation of the gastric mucosa in the stomach, which is common with many supplements and drugs.
What are the Benefits of Enteric Coated Capsules?
For some formulations, Enteric Coated Capsules are an ideal choice. This is because they:
- Overwhelmingly increase absorption rates - The absorption of high quality supplements can increase from as low as 10% (depending on the individual) to 80% or more.
- Will not dissolve in the mouth – Enteric Coated Capsules are perfect for drugs that are acid-activated, as they prevent the drug from activating in the mouth or esophagus.
- Will not irritate the stomach – Many drugs, such as aspirin, can irritate the stomach. Because they pass through the stomach intact, Enteric Coated Capsules avoid this problem.
- Can preserve enzyme activity – Most tablets break down in the highly acidic environment of the stomach. Unfortunately, depending on the product’s formulation, this acidic environment can also negatively impact the desired enzyme activity. Enteric Coated Capsules protect the enzymes so that they can be absorbed, at their highest activity levels, in the small intestine.
- Take longer to dissolve – While most capsules dissolve within 15 minutes, Enteric Coated Capsules do not dissolve until approximately one to two hours after ingestion, when they reach the small intestine. These capsules can therefore provide a “timed-release” affect.
Although enteric coating is a common technology employed with expensive pharmaceutical medications, it is rarely seen in the nutritional supplement industry!
That’s because most supplements are manufactured to a price rather than from a ‘best science’ perspective. Pharmaceuticals always work because they must be based on ‘best science’ since FDA regulations require proof that they work.
The manufacturer of Xtend-Life claims over 80% absorption of ingredients when using enteric coated capsules. An extremely high level for a nutritional or dietary supplement.
Some experts believe that (in non enteric coated products) the bioavailability of vitamins (i.e. all the contents) is only 10-15% due to damage from gastric juices and enzymes in the stomach. This is a gray area however as there is little conclusive research available dealing with absorption rates since so many individual factors come into play from person to person.
SUGGESTED USE: As a dietary supplement, take four (4) capsules one (1) time per day, ideally 60 minutes prior to working out. Do not exceed more than one serving per day.
WARNING: Consult with your physician before using this product. Do not take this supplement if you have any pre-existing medical conditions. This product should not be used by anyone under the age of 18. Athletes, check with your testing organization before using. User assumes all risks and liabilities related to use of this product. Keep out of the reach of children. Keep in a cool, dry place.
I can't wait for everyone's feedback on the new POWER+! A lot went into this formula and I'm extremely excited for this release!
~ Trevor, Owner, AdvancedSupps.com