I have been taking supplements for quite a few years now and I believe my body has built up a tolerance for certain dosages for certain things but overall I got good results.
Breakthrough VASOVUL by Breakthrough Labz
Brand New Muscle & Strength Booster… amplifying muscle hypertrophy, protein synthesis, & follistatin!
VASOVUL is the new essential pre-gym routine supplement
Breakthrough VASOVUL was designed to increase blood flow and muscle cell volume in the gym, increase protein synthesis and follistatin, and muscle hypertrophy for the ultimate workout session and improved strength and muscle building results.
Benefits of Breakthrough VASOVUL:
- Increase muscle hypertrophy
- Improve protein synthesis
- Improve strength and anaerobic endurance
- Increase follistatin & muscle growth
Breakthrough VASOVUL only requires 2 capsules approximately 30-45 minutes before the gym! Take VASOVUL for up to 12 weeks and then take a 4 week break. Breakthrough DENSITY and POWER+ are excellent to stack with VASOVUL or to alternate between. Take alongside Breakthrough IMPACT for added energy and endurance for an amazing workout!
The Ingredient Breakdown
- Creatine HCL - 500mg/serving
- Creatine Gluconate - 500mg/serving
- Arachidonic Acid - 250mg/serving
- Epicatechin - 250mg/serving
- 5a-Hydroxy-Laxogenin - 50mg/serving
Creatine is a naturally occurring chemical found within the body, normally in the muscles. It is also found in certain foods and may be obtained through supplementation. It is widely used among athletes in a wide range of sports for the primary purpose of supplementing exercise performance and promoting lean muscle. Creatine HCL is one of the newest iterations of creatine to hit the market; however, it is also significantly more potent.
One form of creatine most impressive is creatine hydrochloride, which is creatine attached to hydrochloric acid. One study found that creatine hydrochloride was absorbed by the body more than 60% better than creatine monohydrate. This allows for a lower dose of creatine to be needed, as well as enhanced results. It also prevents stomach discomfort and any water retention under the skin that some report with creatine monohydrate.
This is the primary difference between Creatine HCL and other types of creatine like monohydrate. It does not require a loading phase and calls for a significantly smaller dosage while still delivering the same benefits.
Creatine hydrochloride’s main benefit is helping to supplement healthy muscle. This is thought to be due to an increase in the production and supply of ATP to working muscle cells. This also promotes muscular energy, helping to avoid lactic acid build-up and allowing for longer and more intense workouts.
Creatine Gluconate is the new best Creatine formula on the market and with very good reason. As you know Creatine is able to improve your strength and anaerobic endurance levels in the gym significantly. This is achieved by saturating the muscle cell with Creatine which in turn maximizes the production of ATP or adenosine tri-phosphate, which then leads to improved performance. To add to this, Creatine is excellent for bodybuilders once it gets into the muscle cell because it literally draws water in with it leading to a much fuller and thicker looking physique. As you will have noticed, these benefits of Creatine occur once it has reached the muscle cell which is absolutely key to note here because little do people know, but up to 80% of Creatine you supplement on doesn’t even make it past your stomach. Therefore you don’t get the benefit of saturated Creatine levels within the muscle cell.
This is where Creatine Gluconate comes into play, because this is precisely why it is so good, because it focuses on ensuring the Creatine gets to the muscle cell, the place where it absolutely needs to be in order to have any effect on you. The clue is in Gluconate because it is fast acting carbohydrates, such as glucose which ultimately lead to the transportation of Creatine into the muscle cell. Without this, there will only be very small amounts of Creatine reaching the muscle cell. Therefore by ensuring that the Creatine is accompanied with the necessary ingredients in the form of glucose, a super fast acting carbohydrate you will enjoy significantly better strength, endurance and size gains whilst using Creatine Gluconate.
The flip side to the Gluconate factor is that you will be susceptible to Insulin spikes which before training are undesired, because this can promote some fat storage. However, when looking to build mountains of muscle mass on to your frame and grow your strength this doesn’t matter, because it will be minimal and the size gains you make will make up for it.
There you have outlined for you the reasons as to why Creatine Gluconate is so much more effective. Up to 90% of the Creatine you take in will reach the muscle cell which is a massive difference to the 20% regular Creatine formulas will achieve for you.
The many perceived benefits of arachidonic acid, such as overcoming depression, increase muscle mass, and treating arthritis, are consistent with the findings of the wide number of studies conducted.
In the case of muscle gain, studies have shown that an increase in arachidonic acid raises the anaerobic capacity and causes the muscle fibers to thicken as a result of greater protein synthesis.
Bodybuilders use arachidonic acid supplements in order to induce inflammation in their muscle tissues, forcing their muscle to grow in greater size and shape.
It has been found that arachidonic acid’s characteristic of causing small amount of inflammation help muscles contract and become larger. This also makes it helpful for those who wish to lose weight and gain strength through resistance training.
Small amounts of inflammation thus are beneficial for gaining muscle for bodybuilders. The fatty acids present in the acid help muscle fibers utilize protein a lot more efficiently.
Trainers who can benefit most from arachidonic acid supplements are those who have reached training plateaus and won’t to shock their muscles to make greater gains.
There is also a considerable amount of research to show that arachidonic acid helps treat depression.
Researchers found that arachidonic acid has elements that can alleviate symptoms of depression and reverse negative signals in the brain. Arachidonic acid has also been shown to thin out blood that can counter depression a lot more efficiently.
Fish oils are commonly sold as supplements rich in omega-3 fatty acids in order to overcome depression. However, fish oil may not necessarily be rich with omega-3 fatty acids; it all depends on what types of fish have been used to produce the oil and whether the fish had access to a proper habitat.
Therefore, you should always be more cautious about fish oil supplements.
More importantly, arachidonic acid is also associated with treating rheumatoid arthritis.
The study found that participants who took a diet rich in fish oil showed a reduction in swollen joints. This has led researchers to conclude that a diet rich in arachidonic acid can be very effective for treating arthritis.
Despite its lesser-known presence in the nutrition world, ARA is an incredibly important and prominent fatty acid in cell membranes. It is found at a level comparable to that of DHA in neural membranes, including in the brain, where it comprises 10-12% of total fatty acids. In skeletal muscle, ARA has been found to make up 15-17% of total fatty acids.
The body relies on ARA for inflammation, a normal and necessary immune response to repair damaged tissue. Specifically, ARA is the precursor to various leukotrienes, prostaglandins, and thromboxanes, collectively known as eicosanoids. While the majority of ARA-derived eicosanoids act to promote inflammation, some also act to resolve it (i.e., are anti-inflammatory).
Scientists hypothesize that ARA plays a central role in the adaptive response to strength training. After all, strength training causes an acute inflammatory response that’s necessary to build bigger muscles. For instance, two prostaglandins produced from ARA are PGE2 and PGF2α. Test tube studies performed with skeletal muscle fibers indicate that PGE2 increases protein breakdown while PGF2α stimulates protein synthesis. Other test tube studies have also found PGF2α to increase skeletal muscle fiber growth.
In support of these test tube findings, research in young adults has shown that consuming non-steroidal anti-inflammatory drugs (NSAIDs) after exercise blunts the normal increase in muscle protein synthesis through suppressing the normal increase in PGF2α. In contrast, administration of NSAIDs to older adults has been shown to enhance strength and size gains in response to resistance training by suppressing other forms of inflammation in addition to the beneficial PGF2α. Regardless of outcome, this research does clearly indicate a role of ARA-derived prostaglandins in the adaptive response to exercise.
If blunting ARA-derived prostaglandin formation attenuates adaptations to resistance training in young adults, then perhaps the reverse is also true (as shown in Figure 2)—that increasing prostaglandin formation enhances adaptations to resistance training. Supplementation with ARA increases the ARA content of serum phospholipids. This increased availability is associated with increased prostaglandin formation. Accordingly, the current study was designed to examine whether ARA supplementation affected body composition and muscle function in strength-training individuals. This study also used rats to evaluate the effect of ARA supplementation on anabolic signaling mechanisms.
Resistance-trained males underwent an eight-week resistance training program while supplementing 1.5 grams per day of ARA or corn oil placebo. Body composition, muscle strength, and muscle power were assessed before and after the intervention. Additionally, rats were fed either plain water or ARA dissolved in water for eight days, and then had their right hind leg subjected to electrical stimulation to mimic strength training. After that, muscle tissue from both legs was analyzed for anabolic and inflammatory signals.
ARA supplementation led to significantly greater increases in lean body mass, bench press 1RM, and power output than placebo. The rat experiment showed that ARA led to a significant reduction in AMPK and GSK-3β activation when ARA was combined with exercise as compared to the other groups. Other markers of anabolism and catabolism were not affected by ARA treatment, although they were affected by exercise.
This study tells us that young men with resistance training experience may benefit from ARA supplementation through increased lean body mass, muscular strength, and muscular power.
Epicatechin is a strong antioxidant, has insulin mimic action and improves heart health. Dr. Norman Hollenberg of Harvard Medical School found that Kuna indians, who live on the San Blas Island Chain in Panama and drink high quantities of cocoa drinks, have a lower risk of stroke, heart failure, cancer and diabetes compored to the Indians living on the mainland. Dr. Norman Hollenberg even suggests considering epicatechin as a vitamin.
Epicatechin is a flavanol found in certain plants such as green tea and cocoa; and is a powerful antioxidant that helps decrease Myostatin. Myostatin is the greatest single catabolic limiting factor of muscle growth. This natural growth factor protein exists in our bodies and works to regulate and limit muscle growth in a genetically predetermined pattern. Myostatin actually suppresses muscle growth. Epicatechin works to decrease Myostatin which helps to reduce these limiting factors, promoting muscle development beyond your genetic potential.
A recent study has revived the supplement market’s interest in a compound called (-)-epicatechin, a molecule found in chocolate. This molecule is claimed to be a myostatin inhibitor. Myostatin deficiencies are well known for their biggest side effect: greatly increased muscle mass without the major side-effects associated with anabolic steroids. Hindering myostatin’s actions would be able to replicate this effect.
Myostatin is a myokine, a kind of regulating molecule released by muscles. The ‘opposite’ of myostatin is a myokine called follistatin. Unlike myostatin, which suppresses muscular growth, follistatin indirectly promotes muscle growth because it hinders myostatin signalling.
Laxogenin (5a-Hydroxy) is an anabolic building block that is derived from plants, and it can be used by the body to create its own anabolics. It does this by increasing protein synthesis and nitrogen retention, creating an anabolic environment in the body that gives the effects of increased muscle strength and mass, endurance, recovery, and lean gains. What's more, laxogenin also inhibits cortisol - a nasty hormone we get from both mental and physical stress, which signals the body to store fat and burn muscle.
Tests showed that protein synthesis increased by over 200%, the key to lean muscle growth and accelerated repair. In testing, 5a-Hydroxy Laxogenin has balanced cortisol response, which is the major cornerstone to healthy recovery and reduction of muscle wasting.
Laxogenin was isolated in 1992 from rhizomes of smilax sieboldii (a plant species found throughout the world, but native to Asia). It is considered to be a type of steroidal sapogenin, and part of a group called brassinosteroids, which are part of a group of 40 different steroids that are synthesized from species of plants. Within the plant, these amazing compounds promote growth and vitality.
However, a study from the FASEB journal in 2010 showed that these brassinosteroids actually trigger anabolic effects by increasing protein synthesis, while halting protein breakdown. As we all know, protein is the building block of muscle, but with laxogenin you also get such benefits as fat loss and performance enhancement.
Laxogenin is known to be the only compound available that can give you anabolic gains in mass and strength without the steroidal suppression, or other side effects. Therefore, athletes can use it on a caloric restricted diet to prevent loss of muscle and strength. Furthermore, it will also help control glucose and increase thyroid function (metabolism). Besides, according to one experiment from the late 80's in Japan, Laxogenin has been shown to have anti-inflammatory benefits and a prominent anti-tumor potential
As a dietary supplement, take two (2) capsules once per day. Ideally timing the dose 30-45 minutes prior to working out. Take daily for up to 12 consecutive weeks, following by a 4 week break. DO NOT EXCEED 2 capsules in a 24 hour period.
For use by healthy adults only, not recommended for persons under the age of 18. Do not use if you are pregnant or nursing. Individuals should not consume other caffeinated products in conjunction with this product. Seek advice from a healthcare professional before taking if you have any preexisting medical condition to ensure it is safe to take this product. In case of accidental overdose, contact a poison control center immediately. Avoid alcohol or prescription stimulants while taking this product. Exceeding recommended serving will not improve results and may cause serious adverse health effects. Discontinue use of Vasovol and contact a licensed healthcare professional immediately if you experience an unusually rapid heartbeat, dizziness, severe headache, or shortness of breath. KEEP OUT OF THE REACH OF CHILDREN.
The product did seem to help increase vascularity and maybe helped grind out an extra rep on medium weight sets. However, I did not notice any effects on body comp or strength in my heavier sets.